hexanedioyl dichloride

hexanedioyl dichloride - Names and Identifiers

Name	Adipoyl chloride
Synonyms	adipoyl Hexyl Dichlroide Adipoyl chloride Adipyl dichloride Adipic dichloride adipoyl dichloride Adipic acid dichloride hexanedioyl dichloride Hexanedioic acid dichloride 1,4-Bis(Chlorocarbonyl)butane 1,4-Butanedicarbonyl chloride~Hexanedioyl dichloride
CAS	111-50-2
EINECS	203-876-4
InChI	InChI=1/C6H8Cl2O2/c7-5(9)3-1-2-4-6(8)10/h1-4H2

hexanedioyl dichloride - Physico-chemical Properties

Molecular Formula	C6H8Cl2O2
Molar Mass	183.03
Density	1.259g/mLat 25°C(lit.)
Melting Point	262-264 °C
Boling Point	105-107°C2mm Hg(lit.)
Flash Point	>230°F
Water Solubility	reacts
Vapor Presure	0.00557mmHg at 25°C
Appearance	Liquid
Color	Clear brown
BRN	507709
Storage Condition	Store below +30°C.
Stability	Stability Reacts violently with water to form hydrochloric acid. Incompatible with water, alcohols, bases, oxidizing agents. Protect from moisture.
Sensitive	Moisture Sensitive
Refractive Index	n20/D 1.471(lit.)
Physical and Chemical Properties	Colorless or light yellow liquid. Boiling point 126(1.60kPa),105-107 ℃(0.27kPa), relative density 0.963, refractive index 1.4263, flash point 50 ℃. Can be miscible with ether and benzene, water and alcohol decomposition.

hexanedioyl dichloride - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R34 - Causes burns R29 - Contact with water liberates toxic gas R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R14 - Reacts violently with water
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S8 - Keep container dry.
UN IDs	UN 3265 8/PG 2
WGK Germany	3
FLUKA BRAND F CODES	10-21
TSCA	Yes
HS Code	29171900
Hazard Class	8
Packing Group	II

hexanedioyl dichloride - Nature

Open Data Verified Data

colorless or light yellow liquid. The relative density was 0.963. Boiling point 126 ℃(1. 6kPa). Decomposition in water and alcohol. Refractive index 4263. Flash point 50 °c.

Last Update：2025-06-10 22:55:16

hexanedioyl dichloride - Preparation Method

Open Data Verified Data

adipic acid was used as a raw material, and thionyl chloride was used for chlorination at 90-95 ° C. To obtain a crude product, and the reaction product was refluxed and distilled under reduced pressure to remove the remaining thionyl chloride, thereby obtaining a finished adipyl chloride.

Last Update：2022-01-01 10:32:29

hexanedioyl dichloride - Application

Open Data Verified Data

organic intermediates. It is used in medicine to synthesize bile acid.

Last Update：2025-08-19 16:24:40

hexanedioyl dichloride - Safety

Open Data Verified Data

This product is toxic. There is a strong corrosive, water absorption, easy to decompose, produce hydrogen chloride gas. Operators should wear protective equipment, equipment should be sealed to prevent leakage. The workshop should be well ventilated.
glass bottle packaging, should be waterproof, sunscreen, sealed. Transport according to the regulations of toxic chemicals.

Last Update：2025-06-10 22:55:16

hexanedioyl dichloride - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Use	organic intermediates. It is used in medicine to synthesize bile acid.
production method	reaction between adipic acid and thionyl chloride: put adipic acid and thionyl chloride into a reaction Pan, reflux and chloride at 90-95 ℃ for 5H, the residual thionyl chloride was removed under reduced pressure to obtain the final product. Raw material consumption quota: Adipic acid 830kg/t, thionyl chloride 1660kg/t.

Last Update：2024-04-10 22:29:15